Ideas and examples of developing traditional Chinese medicine compound new drugs based on ancient classic prescriptions-Taking Chaigui granule, a new chemical drug of Xiaoyaosan, as an example

ZHAO Yunhao; ZHANG Lizeng; TIAN Junsheng; QIN Xuemei

doi:10.12405/j.issn.2097-1486.2022.02.008

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Ideas and examples of developing traditional Chinese medicine compound new drugs based on ancient classic prescriptions-Taking Chaigui granule, a new chemical drug of Xiaoyaosan, as an example

更新时间：2024-11-01

- Ideas and examples of developing traditional Chinese medicine compound new drugs based on ancient classic prescriptions-Taking Chaigui granule, a new chemical drug of Xiaoyaosan, as an example
- Emerging Science and Technology Vol. 1, Issue 2, Pages: 210-216(2022)
- 作者机构：
  
  山西大学　中医药现代研究中心，山西　太原　030006
- 作者简介：
- 基金信息：
- DOI：10.12405/j.issn.2097-1486.2022.02.008
  CLC： R283
- Published：2022-12，
  
  Received：03 October 2022，
  
  Revised：05 December 2022，
- 稿件说明：
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ZHAO Yunhao, ZHANG Lizeng, TIAN Junsheng, et al. Ideas and examples of developing traditional Chinese medicine compound new drugs based on ancient classic prescriptions-Taking Chaigui granule, a new chemical drug of Xiaoyaosan, as an example. [J]. Emerging Science and Technology, 2022,1(2):210-216.
DOI：

ZHAO Yunhao, ZHANG Lizeng, TIAN Junsheng, et al. Ideas and examples of developing traditional Chinese medicine compound new drugs based on ancient classic prescriptions-Taking Chaigui granule, a new chemical drug of Xiaoyaosan, as an example. [J]. Emerging Science and Technology, 2022,1(2):210-216. DOI： 10.12405/j.issn.2097-1486.2022.02.008.

摘要

古代经典名方是中华民族千年来临床实践过程中形成的疗效确切的方剂，是中药复方创新药研发的重要源头，本文以逍遥散化裁研发新药柴归颗粒为例，通过总结逍遥散基础研究到创新药开发的历程，提出临床需求、资源禀赋和确方充分的“三要素”选题依据，探索了中医药理论、人用经验和临床试验“三结合”的处方化裁路径，形成了阐明新机制、配伍新处方和研制新剂型的创新药“三新”研发策略。

Abstract

The ancient classic famous prescription is a prescription with definite curative effect formed in the course of clinical practice of the Chinese nation for thousands of years. It is an essential source of research and development of new drugs in traditional Chinese medicine. This paper takes the research and development of Chaigui granules

a new drug of Xiaoyaosan

as an example. By summing up the process from basic research of Xiaoyaosan to the development of innovative medicines

it puts forward the basis for selecting the topic of "three elements" with sufficient clinical needs

resource endowments

and accurate prescriptions to explore the drug of "three combinations" of traditional Chinese medicine theory

human experience

and clinical trials. It forms the "three new" research and development strategy of innovative drugs that clarify the new mechanism

compatibility with new prescriptions

and develop new dosage forms.

关键词

经典名方中药创新药研发逍遥散柴归颗粒研究思路

Keywords

classic prescriptionsnew drug developmentXiaoyao SanChaigui granuleresearch strategy

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