摘要:Fluorescent probes can detect biological macromolecules, active oxygen species, active sulfur species, metal ions, etc. via fluorescence signal changes of the functional modification of fluorescent dyes. Their non-destructive labeling and detecting properties are favored by life science researchers. In recent years, with the joint innovation of dye chemical industry, organic synthetic chemistry and fluorescence imaging technology, fluorescence imaging has continuously made new breakthroughs in in situ labeling in vivo, which has effectively promoted the development of fluorescence imaging technology from basic research to pre-clinical application. This paper starts from the basic concept of fluorescent probe, combined with the representative research results of our team and others. It discusses the correlation between fluorescent probes and the signal-to-noise ratio of fluorescence imaging in vivo, and the application prospects of promoting molecular level cognition in life science.
关键词:fluorescent probe;fluorescence imaging;signal-to-noise ratio;in vivo
摘要:With the development of computer technology, the field of combustion science and engineering is advancing towards digitization, automation, and efficiency. In order to keep pace with scientific advancements and demands, the Technical University of Munich is establishing a digital fuel center for research and development in renewable fuels/energy, novel high-efficiency environmentally friendly fuels, combustion machinery, and aerospace propulsion technology. This article takes the optimization of the methanol combustion chemical kinetics model as an example to demonstrate the application of digitalization and artificial intelligence optimization algorithms for experimental and model parameters. This work presents an automatic optimization tool using a genetic algorithm for the chemical kinetic model of methanol combustion. 54 parameters including reaction rate constants and third body efficiencies for 40 important reactions and selected species of the reaction model have been optimized. Experimental data for model validation include: ignition delay times measured in shock tubes and concentration profiles measured in plug flow reactors. Homogeneous modeling of the methanol oxidation was conducted with the open-source tool Cantera in Python and the simulated ignition delay times and concentrations were optimized using the genetic algorithm programed in Python. The prediction ability of the optimized model has been improved compared with the initial model based on the estimated reaction rate constants. The developed genetic algorithm tool was proved to be able to optimize the detailed chemical kinetic model.
摘要:As the development of experimental technology, periodic driving plays an important role in fields such as quantum control, quantum simulation and precision measurement. This article starts from the Floquet theory that deals with periodic driving, and focuses on the applications of different periodic control sequences in dynamical decoupling and extending the coherence time of systems, as well as the use of periodic control in discovering novel quantum states such as anomalous bulk-edge correspondence, dynamical gauge field, discrete time crystal, etc. In addition, theoretical research on periodic driving in open systems needs to be developed urgently.
关键词:periodic driving;dynamical decoupling;novel quantum states
摘要:Thermalization is the inevitable fate of a general complex quantum many-body system, whose dynamics allow it to fully explore the configuration space regardless of the choice of initial state which is known as quantum ergodicity. The quantum ergodicity is governed by the so-called Eigenstate Thermalization Hypothesis (ETH), which explains the quantum thermalization process of a system at the level of energy eigenstates and serves as a key to understanding quantum many-body chaos and thermalization phenomena. Nevertheless, ETH is a hypothesis after all and there exist counter-examples such as quantum integrable systems and many-body localized systems. The former has an infinite number of intrinsic conserved quantities, while the latter has an infinite number of emergent conserved quantities induced by disorder and interaction. The extensive conserved quantities make the system avoid being thermalized because in principle they can determine each eigenstate in the system. In recent years, non-thermal dynamic behavior has been discovered in ultracold atom quantum simulators with Rydberg atomic arrays. It had been observed that some particular initial states exhibit periodic non-thermal dynamics. This phenomenon occurs in non-integrable and disorderless systems which is considered a new mechanism that violates ETH named as quantum many-body scars. In this paper, we will briefly review the quantum scar phenomenon in ultracold atoms, and discuss the physical mechanism of this phenomenon. We then introduce a simple quasiparticle excitation picture to vividly demonstrate the quantum many-body scarring phenomena in the Rydberg atomic chain.
摘要:Attosecond pulses provide new means to probe the motion law of the microcosmic world under the natural time scale of electron motion, promoting new developments in physics, chemistry, and biology, etc. The high harmonic generation, as an important method to synthesize attosecond pulses, has been widely studied. This paper reviews the important progress in detecting the atomic and the molecular structures and the electric ultrafast dynamics, and the progress of the high harmonic spectroscopy in revealing the deep-lying orbitals dynamics and electron correlation effects. It also introduces the applications of high harmonic spectroscopy in molecular orbital tomography, following chemical reactions and detecting charge migration.
摘要:Vacuum has been a controversial philosophical issue since the ancient Greek era. This article summarizes the discussion of “vacuum” at different stages of modern physics, from classical Newtonian mechanics to relativity, quantum mechanics, and quantum field theory, etc., including in various theories, the concept, the theory, and the experiment of vacuum.
关键词:vacuum;classical physics;quantum;vacuum not being empty
摘要:It is found that the murals in Kaihua Temple in Gaoping, Shanxi Province are endangered by such diseases as mural fading, floating dust, rain stains, paint layer shedding and cracking, etc. The current situation of the remains is not optimistic. In order to promote the protection of the murals, it is meaningful and feasible to apply the material genome idea to the polymer mural restoration materials. Based on the above investigation, the design of applying the material genome idea to the polymer mural restoration materials includes the following steps: determination of gene parameters, construction of calculation model, database establishment and database retrieval.
摘要:This paper compares different paths in the development of molecular biology between China and the West in the 1950s and the 1970s, and then analyzes the reasons for this phenomenon. It was not entirely the scientists’ lack of understanding of the international mainstream, nor the country’s excessive emphasis on integrating theory with practice, However, it was the research limitations caused by an erroneous understanding of the genetic theory during a period of time and the scientists’ limitations on specific topics under special historical conditions. The research efficiency then was not that high in the field of molecular biology. In this regard science should follow its own development laws; moreover scientists’ dominant position should be further strengthen in the scientific research work.
关键词:molecular biology;International mainstream;Subjectivity of research direction;degree of freedom
摘要:With the Era of Intelligent Machine Revolution represented by information technology and intelligence, today’s society are undergoing fundamental changes, Human’s way of production, lifestyle, and even way of thinking will also undergo revolutionary changes. The global popularization of intelligent way of production and the widespread application of intelligent machines will increasingly promote the diversified transformation of human life concept in the process of the overall progress of human civilization and the intelligent lifestyle shift, and will continuously stimulate and amplify human life potential, promoting people, who have more conditions and abilities to pursue more personalized lifestyles and diversified life meanings. Analyzing in depth the general characteristics of the revolutionary change to promote the true realization of human’s good life and comprehensive development, is not only related to the human’s social survival and social practice, but also to the improvement of people’s well-being and the reconstruction of social order of the whole world.
关键词:Intelligent Machine Revolution;life concept;human development;good life